PhD Studentship - Xenobiotic Exposure as a Trigger for Primary Biliary Cirrhosis, Institute of Cellular Medicine
* Institute: Institute of Cellular Medicine and the Medical Toxicology Unit
* Sponsor: The British Toxicology Society
* Supervisor(s): Dr Matthew C Wright, Professor Peter G Blain and Professor Faith M Williams
* Duration: 3 years from 1 October 2008
Project description
Primary biliary cirrhosis (PBC) is a liver disease of unknown aetiology characterised by the destruction of the intra-hepatic bile ducts, cholestasis, liver cirrhosis and death. The only treatment at present is liver transplantation. PBC is often thought to be an auto-immune disease. However, the auto-antigens exist in all cells of the body, yet inflammation is restricted to the bile ducts.
The aims of this project are to screen a range of xenobiotics for their oestrogenic activity in hepatocytes and for their ability to modulate mitochondrial polarisation in hepatocytes and bile duct epithelial cells. Bile duct inflammation will then be examined in an animal model of PBC using selected xenobiotics shown to have both oestrogenic and mitochondrial effects.
Person specification
The studentship is available to UK and EU applicants with an upper-second class degree or higher in a biologically-related subject or equivalent.
Value of the award
The award covers fees and a stipend of £13,000 per annum.
How to apply
You must complete the University’s postgraduate application form (http://www.ncl.ac.uk/postgraduate/apply), quoting the reference number CAL44, and attaching a copy of your CV and covering letter. Select PhD in Medical Sciences as the programme of study.
Further information
Please contact Dr Matthew Wright (m.c.wright@ncl.ac.uk), tel: +44 (0) 191 222 7094.
Closing date: 2 May 2008.
Funding information : EU applicants (including UK)
No comments:
Post a Comment